The INHALE Study

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The INHALE Study

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The INHALE Study - Logo

INHALE: INvestigation of H01 for the Avoidance of Lung Events for COVID-19 patients


 

The INHALE Study - global COVID19 landscape

We urgently need accessible, effective drugs for COVID-19

Vaccines are unlikely to cover the major centers of the world before the end of 2021 


We need an inexpensive, oral medicine to manage COVID-19 lung disease and death worldwide

the INHALE Study - H01 manufacturing and landscape for COVID19

H01 repurposing a safe, accessible oral drug for COVID-19

New research from the Stanford University School of Medicine suggests an existing EMA-approved oral drug has high potential to treat respiratory distress resulting from COVID-19


H01 (Hymecromone) is approved in multiple countries and available with existing manufacturing capabilities across the globe

The INHALE study tests H01 for inhibition of hyaluronan synthesis in COVID19

Reduce hyaluronan, breathe easier

Hyaluronan is a long-chain glycosaminoglycan secreted in response to SARS-CoV-2 infection. This excess hyaluronan promotes fluid accumulation and gas exchange  


H01 (Hymecromone) is an inhibitor of hyaluronan synthesis. EMA-approved and used globally for over 50 years, H01 has a strong record of safety and tolerability in humans


We believe that by repurposing H01 to inhibit hyaluronan synthesis, we can treat COVID-19 associated respiratory distress by reducing fluid accumulation, improving gas exchange, and blood oxygenation

Our Science
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H01: Unique mechanism to addresses unmet need, both in and out of hospital

The INALE Study

The INHALE Study is an investigator-initiated, international, multi-center, randomized controlled trial evaluating H01 (Hymecromone) in COVID-19   



Study Plan

Coverage of hyaluronan in COVID-19

"Bradykinin and the Coronavirus" - Derek Lowe's In the Pipeline


"A Supercomputer Analyzed Covid-19 — and an Interesting New Theory Has Emerged" - Elemental (Medium)


"Bradykinin Hypothesis of COVID-19 Offers Hope for Already-Approved Drugs" - BioSpace

Contact

Presentation - August 2020

200804 - H01 for COVID19 Overview (pdf)Download

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