Hyaluronan is a viscous, hygroscopic polymer. One gram of hyaluronan trap up to 1000x its mass in water
In response to COVID-19 infection, lung cells secrete hyaluronan into the airways
Excess hyaluronan accumulates in alveoli of COVID19 patients
Excess hyaluronan pulls water, reducing gas exchange, driving respiratory failure, and ultimately driving intubation and mortality
Hyaluronan is a long-chain glycosaminoglycan secreted in response to SARS-CoV-2 infection. This excess hyaluronan promotes fluid accumulation and gas exchange
H01 (Hymecromone) is an incidental inhibitor of hyaluronan synthesis. EMA-approved and used globally for over 50 years, H01 has a strong record of safety and tolerability in humans
We believe that by repurposing H01 to inhibit hyaluronan synthesis, we can treat COVID-19 associated respiratory distress by reducing fluid accumulation, improving gas exchange, and blood oxygenation
A preliminary pharmacodynamic study suggests H01 (Hymecromone) suggests a dose-response effect on induced sputum hyaluronan
Andonegui-Elguera S, Taniguchi-Ponciano K, Gonzalez-Bonilla CR, et al. Molecular Alterations Prompted by SARS-CoV-2 Infection: Induction of Hyaluronan, Glycosaminoglycan and Mucopolysaccharide Metabolism. Arch Med Res. 2020;S0188-4409(20)30705-0.
Cardone M, Yano M, Rosenberg AS and Puig M (2020) Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation. Front. Immunol. 11:1131.
Michael A Mong, Jacob A Awkal, Paul E Marik. Accelerated hyaluronan concentration as the primary driver of morbidity and mortality in high-risk COVID-19 patients: with therapeutic introduction of an oral hyaluronan inhibitor in the prevention of Induced Hyaluronan Storm Syndrome. medRxiv 2020.04.19.20071647
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